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Successful endovenous thermoablation relies on transmural vein wall ablation. We investigated the pattern of thermal spread and tissue carbonisation from RadioFrequency-induced ThermoTherapy (RFiTT) at different powers and pull back methods, using a porcine liver model.<br />We used a previously validated<br />porcine liver model. Different powers from 5-25 W were used to administer 150 J. We compared continuous and pulsed energy delivery. Length, lateral spread, and total area of thermal damage, together with any tissue carbonisation, was measured using digital analysis software.<br />All experiments used 150 J total energy. Total thermal damage area was smaller with lower power and pulsed energy. Continuous energy caused more tissue carbonisation than pulsed except at 25 W.<br />Reduced thermal damage with lower power or pulsed energy results from cooling due to increased time of treatment. Increasing the power increases tissue carbonisation. Optimal treatment is determined by the highest power used continuously that does not cause tissue carbonisation.<br />Reduced thermal damage with lower power or pulsed energy results from cooling due to increased time of treatment. Increasing the power increases tissue carbonisation. Optimal treatment is determined by the highest power used continuously that does not cause tissue carbonisation.Objective. Humans have limited power and require mechanization, to meet high energy demand, through equipment. We initiated this study to accumulate data from previous research to identify critical issues and approaches in implementing ergonomic principles into the design, intervention, development and assessment of manually operated equipment. Method. The literature search was carried out in scientific databases Scopus and PubMed. Fifty-three research articles, meeting the inclusion criteria, were selected for this review. [https://www.selleckchem.com/products/cay10603.html CAY10603 order] Results. The study indicated a propensity of countries with lower-middle-income and high-income groups, and of the agricultural and manufacturing sector toward research and development of manually operated equipment. A thorough study of the equipment design process revealed that health and safety was the prime motivator in the pre-design phase, an experimental prototype approach was most utilized in the design phase and a direct measurement technique was most frequently used in the post-design phase. Conclusion. The study highlights the scarcity of research in the integration of ergonomics into the design of manually operated equipment among countries with the low-income group. This study also promotes the use of virtual design and assessment techniques for cost-effectiveness.<br />There is an obvious need for efficient measurement of neuropsychiatric phenomena. A proven method-computerized adaptive testing (CAT)-is not feasible for all tests, necessitating alternatives for increasing test efficiency.<br />We combined/compared two methods for abbreviating rapid tests using two tests unamenable to CAT (a Continuous Performance Test [CPT] and n-back test [NBACK]). N=9,498 (mean age 14.2 years; 52% female) were administered the tests, and abbreviation was accomplished using methods answering two questions what happens to measurement error as items are removed, and what happens to correlations with validity criteria as items are removed. The first was investigated using quasi-CAT simulation, while the second was investigated using bootstrapped confidence intervals around full-form-short-form comparisons.<br />Results for the two methods overlapped, suggesting that the CPT could be abbreviated to 57% of original and NBACK could be abbreviated to 87% of original with the max-acceptable loss of precision and min-acceptable relationships with validity criteria.<br />This method combination shows promise for use in other test types, and the divergent results for the CPT/NBACK demonstrate the methods' abilities to detect when a test should not be shortened. The methods should be used in combination because they emphasize complementary measurement qualities precision/validity..<br />This method combination shows promise for use in other test types, and the divergent results for the CPT/NBACK demonstrate the methods' abilities to detect when a test should not be shortened. The methods should be used in combination because they emphasize complementary measurement qualities precision/validity..Background The objective of this study was to evaluate the performance characteristics of early commercial SARS-CoV-2 antibody assays in mild and asymptomatic subjects to enable the selection of suitable immunoassays for routine diagnostic use. Methods We used serum samples from a pre-COVID era patient cohort (n = 50, pre-December 2019), designated SARS-CoV-2 negative, and serum samples from a SARS-CoV-2 RT-PCR-positive cohort (n = 90) taken &gt; 14 days post-symptom onset (April-May 2020). Six ELISA assays were evaluated, including one confirmation assay to investigate antibody specificity. We also evaluated one point-of-care lateral flow device (LFIA) and one high throughput electrochemiluminescence immunoassay (CLIA). Results The ELISA specificities ranged from 84% to 100%, with sensitivities ranging from 75.3% to 90.0%. The LFIA showed 100% specificity and 80% sensitivity using smaller sample numbers. The Roche CLIA immunoassay showed 100% specificity and 90.7% sensitivity. When used in conjunction, the Euroimmun nucleocapsid (NC) and spike-1 (S1) IgG ELISA assays had a sensitivity of 95.6%. The confirmation Dia.Pro IgG assay showed 92.6% of samples tested contained both NC and S1 antibodies, 32.7% had NC, S1 and S2 and 0% had either S1 or S2 only. Conclusions The Roche assay and the Euroimmun NC and S1 assays had the best sensitivity overall. Combining the assays detecting NC and S1/S2 antibody increased diagnostic yield. These first-generation assays were not calibrated against reference material and the results were reported qualitatively. A portfolio of next-generation SARS-CoV-2 immunoassays will be necessary to investigate herd and vaccine-induced immunity.Implementing anammox based processes in the mainstream at municipal wastewater treatment plants is challenging and requires carefully constructed control strategies in order to be successful. A method to measure the specific anammox activity was further developed and implemented in the mainstream anammox pilot plant at Sjölunda Wastewater Treatment Plant. The method was found to be reliable and reproducible. The influence of initial nitrite and ammonium concentrations on the activity as well as temperature dependency were analysed. The continuously monitored manometric batch tests were performed on Moving Bed Biofilm Reactor carriers type K1®. The activity showed a dependency of initial nitrite concentrations below 75 mg N L-1 whereas the activity was independent of initial nitrite concentrations in the interval of 75-125 mg N L-1. Temperature dependency of the specific anammox activity as expressed in activation energy Ea increased at lower temperatures (10-20°C) compared to higher temperatures (20-30°C). Decreasing temperature from 30°C to 10°C resulted in 95-98% loss of the anammox activity.