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5% vs. 99.4%,<br /> = 0.2). At the higher sensitivity threshold, the algorithm was significantly more sensitive than reader A (99.4% vs. 89.4%, p &lt; 0.001) and reader B (99.4% vs. 94.4%,<br /> = 0.02) and identical to the consensus sensitivity (99.7% in both cases,<br /> = 1.0). There were no significant differences in the detection capability of the AI system by tumour type, grading and density.<br />In this proof of principle study, we show that sensitivity using single reading with a suitable AI algorithm is non-inferior to that of standard of care using 2D mammography with double reading, when tomosynthesis is the primary screening examination.<br />In this proof of principle study, we show that sensitivity using single reading with a suitable AI algorithm is non-inferior to that of standard of care using 2D mammography with double reading, when tomosynthesis is the primary screening examination.Co-production can inform analysis and communication of the uncertainties associated with novel forms of science and technology. Genomic selection-a relatively novel management tool consisting of predictive modeling based on associations between genetic and phenotypic data-holds many unknowns, particularly when used as a climate adaptation strategy. Approaching genomic selection as an example of public science, we examined beliefs about uncertainty and public engagement in a community of forest research professionals. Findings show broad-ranging approaches to uncertainty, alongside a prevalence of deficit accounts of public engagement. Even with broad acknowledgment of a range of uncertainties, forestry experts nonetheless relied on statistical, quantitative methods to manage uncertainties, in ways that overshadowed discussions about ignorance, indeterminacy, and ambiguity. Social scientists can enhance the communication of uncertainty in public science by making apparent expert-based assumptions about knowledge and intended audiences.The body status of livestock affects their physiological function and productive performances. Microsatellites, one of the most used DNA markers, have been found to be associated with pig productive traits. However, their identifications and effects on body measurement traits of the Chinese Qinghai Bamei pig still uncovered. According to our previous sequencing data, in this study, three novel microsatellites were found in this breed. Using time of flight-mass spectrometry (TOF-MS) method, these microsatellites were further identified in a large Bamei pig population. TOF-MS spectra showed that there are three microsatellites loci, named P1, P2 and P3. These microsatellites were linkage equilibrium based on the values of D' and r2 tests. Association results demonstrated that P1 locus was associated with the body length, body height and chest width and the beneficial genotype was 150-/150-bp (p  less then  0.05); and P2 locus was associated with the body height (p  less then  0.05), and the 145-/145-bp, 145-/147-bp and 145-/149-bp were claimed as favorable genotypes and 145-bp allele was considered as the favorable allele. These findings suggested that P1 and P2 microsatellites might be considered as the candidate genetic markers to select pigs with superior body sizes, especially in local breed.Victims often perceive aggressive behaviors as being more harmful than do perpetrators-a so-called victim-perpetrator asymmetry. We examined whether this victim-perpetrator asymmetry was especially strong for individuals who were high in trait hostility. In two studies-one where participants recalled actual aggressive experiences and one where participants took the perspective of a person in a vignette-we found that victims who were high in trait hostility, relative to those who were low, viewed aggressive behaviors as being most harmful. We found somewhat inconsistent effects for whether perpetrators viewed the aggressive behaviors as more justified than victims did and whether trait hostility moderated this judgment. Collectively, the current findings show that victims who are high in trait hostility are especially likely to view an aggressive behavior as harmful, which potentially makes conflict resolution difficult for these individuals and increases the likelihood they would retaliate.The influence of hyperlipidemia on titanium implant osseointegration and the underlying mechanisms is not well understood. This study investigates the changes in osseointegration and explores the potential mechanisms in hyperlipidemia conditions. In vivo, specialized titanium implants were implanted in the femurs of diet-induced or genetic hyperlipidemia mice. In vitro, primary murine osteoblasts were cultured on the titanium surface in high-fat medium. Results showed that hyperlipidemia led to poor osseointegration in both types of mice in vivo, and high-fat medium impaired the osteogenic differentiation of primary osteoblasts on the titanium surface in vitro. In addition, high-fat medium caused significant overproduction of reactive oxygen species (ROS) and inhibition of the Wnt/β-catenin pathway in osteoblasts. Both N-acetyl-L-cysteine (NAC, an ROS antagonist) and Wnt3a (an activator of the Wnt/β-catenin pathway) attenuated the poor osteogenic ability of osteoblasts. In addition, NAC reactivated the Wnt/β-catenin pathway in osteoblasts under high-fat stimulation. These results demonstrate that hyperlipidemia impairs osseointegration via the ROS/Wnt/β-catenin pathway and provide support for the ROS or Wnt/β-catenin pathway as a promising therapeutic target for the development of novel drugs or implant materials to improve the osseointegration of implants in hyperlipidemic patients.Essentially, root fillings are performed to preserve natural teeth. Over time, however, some root-filled teeth will inevitably be extracted. The aim of this historical prospective cohort study in the adult Swedish population was to identify factors associated with extractions within 5 y of registration of a root filling. The cohort consisted of all those whose root fillings had been reported to the tax-funded Swedish Social Insurance Agency (SSIA) in 2009. Demographic data on the individuals registered with a root filling (sex, age, country of birth, disposable income, educational level, and marital status) were received from Statistics Sweden or the SSIA. [https://www.selleckchem.com/products/crenolanib-cp-868596.html selleck inhibitor] Dental care setting, tooth type, and any registration of subsequent restorations within 6 mo were received from the SSIA. Multivariable regression analysis was used, and P less then 0.05 was considered statistically significant. In total, 216,764 individuals had been registered with at least 1 root filling. Individuals (n = 824) without complete data were excluded from the analyses.