Characterizing soreness throughout longterm survivors of childhood cancer

Soft enolization conditions are revealed to be markedly better than the typically applied hard enolization protocols for regioselective enoxysilane formation from unsymmetrical 3-substituted cycloalkanones. Five-, six-, and seven-membered cycloalkanones each with 3-methyl, 3-isopropyl, or 3-phenyl substituents were investigated, and in all but one case, regioselectivities were ≥111 for enolization away from the substituent. These results are complementary to the regiospecific enoxysilane formation derived from cycloalkenone conjugate addition/enolate silylation.Motional narrowing is a phenomenon by which a quantum state can be entangled with a noisy environment and still retain its intrinsic coherence. Using two optically induced motional forces driving the environmental electrical field amplitude and fluctuations, we present a compelling illustration of the effects of motional narrowing on the energy, line shape, and line width of a single quantum emitter, a Te2 molecule embedded in ZnSe, subject to spectral diffusion. Motional narrowing is achieved in several regimes, irrespectively of the inhomogeneous disorder initially present and the charge reservoir state sourcing the field. The optimal coherence limit set by the radiative rate can be approached by accelerating spectral diffusion into the THz regime. Motional narrowing applies to any quantum systems for which environmental fluctuations can be deliberately accelerated and alleviates the need for perfected materials and devices.The 14π-electron system of anthracene has been merged with the unsaturated Z-1,2-difurylethene to form a macrocycle(s) with the retained local conjugation of all incorporated subunits that were substantially modulated with a redox activation, opening a global delocalization involving all integrated aromatics. In addition, the edge modulation of acene via the attachment of a specific isomer of the conjugated system gives steric confinements that are characteristic of small macrocycles, forcing substantially short C(H)···O electrostatic interactions that are documented spectroscopically with the support of X-ray analysis.As essential units in an artificial neural network (ANN), artificial synapses have to adapt to various environments. In particular, the development of synaptic transistors that can work above 125 °C is desirable. However, it is challenging due to the failure of materials or mechanisms at high temperatures. Here, we report a synaptic transistor working at hundreds of degrees Celsius. It employs monolayer MoS2 as the channel and Na+-diffused SiO2 as the ionic gate medium. A large on/off ratio of 106 can be achieved at 350 °C, 5 orders of magnitude higher than that of a normal MoS2 transistor in the same range of gate voltage. The short-term plasticity has a synaptic transistor function as an excellent low-pass dynamic filter. Long-term potentiation/depression and spike-timing-dependent plasticity are demonstrated at 150 °C. An ANN can be simulated, with the recognition accuracy reaching 90%. Our work provides promising strategies for high-temperature neuromorphic applications.Internal conversion between valence-localized and dipole-bound states is thought to be a ubiquitous process in polar molecular anions, yet there is limited direct evidence. Here, photodetachment action spectroscopy and time-resolved photoelectron imaging with a heteropolycyclic aromatic hydrocarbon (hetero-PAH) anion, deprotonated 1-pyrenol, is used to demonstrate a subpicosecond (τ1 = 160 ± 20 fs) valence to dipole-bound state internal conversion following excitation of the origin transition of the first valence-localized excited state. The internal conversion dynamics are evident in the photoelectron spectra and in the photoelectron angular distributions (β2 values) as the electronic character of the excited state population changes from valence to nonvalence. The dipole-bound state subsequently decays through mode-specific vibrational autodetachment with a lifetime τ2 = 11 ± 2 ps. These internal conversion and autodetachment dynamics are likely common in molecular anions but difficult to fingerprint due to the transient existence of the dipole-bound state. Potential implications of the present excited state dynamics for interstellar hetero-PAH anion formation are discussed.We demonstrate a high-quality spin-orbit torque nano-oscillator comprised of spin wave modes confined by the magnetic field by the strongly inhomogeneous dipole field of a nearby micromagnet. This approach enables variable spatial confinement and systematic tuning of magnon spectrum and spectral separations for studying the impact of multimode interactions on auto-oscillations. We find these dipole-field-localized spin wave modes exhibit good characteristic properties as auto-oscillators─narrow line width and large amplitude─while persisting up to room temperature. We find that the line width of the lowest-lying localized mode is approximately proportional to temperature in good agreement with theoretical analysis of the impact of thermal fluctuations. This demonstration of a clean oscillator with tunable properties provides a powerful tool for understanding the fundamental limitations and line width contributions to improve future spin-Hall oscillators.Group 13 metal complexes have emerged as powerful catalysts for transforming CO2 into added-value products. However, direct comparisons of reactivity between Al, Ga, and In catalysts are rare. We report aluminum (1), gallium (2), and indium (3) complexes supported by a half-salen H[PNNO] ligand with a pendent phosphine donor and investigate their activity as catalysts for the copolymerization of CO2 and cyclohexene oxide. In solution, the P-donor is dissociated for the Al and Ga complexes while for the In complex it exhibits hemilabile behavior. The indium complex shows higher conversion and selectivity than the Al or Ga analogues. The mechanism of the reaction was studied by NMR and FTIR spectroscopy experiments as well as structural characterization of off-cycle catalytic intermediate indium trichloride complex [(PNNO)InCl3][TBA] (4). This study highlights the impact of a hemilabile phosphine group on group 13 metals and provides a detailed analysis of the initiation step in CO2/epoxide copolymerization reactions.α-Aminophosphonate analogues containing a phthalazine skeleton were efficiently obtained by a new transition-metal-free addition of dialkyl phosphites to phthalazin-2-ium bromide under mild conditions. A mechanistic study using isotope labeling and radical inhibition experiment revealed that the present transformation passes through a nucleophilic addition of dialkyl phosphates, rather than an insertion of P-H to carbenes.Li-rich rocksalt oxides are promising candidates as high-energy density cathode materials for next-generation Li-ion batteries because they present extremely diverse structures and compositions. Most reported materials in this family contain as many cations as anions, a characteristic of the ideal cubic closed-packed rocksalt composition. In this work, a new rocksalt-derived structure type is stabilized by selecting divalent Cu and pentavalent Sb cations to favor the formation of oxygen vacancies during synthesis. The structure and composition of the oxygen-deficient Li4CuSbO5.5□0.5 phase is characterized by combining X-ray and neutron diffraction, ICP-OES, XAS, and magnetometry measurements. The ordering of cations and oxygen vacancies is discussed in comparison with the related Li2CuO2□1 and Li5SbO5□1 phases. The electrochemical properties of this material are presented, with only 0.55 Li+ extracted upon oxidation, corresponding to a limited utilization of cationic and/or anionic redox, whereas more than 2 Li+ ions can be reversibly inserted upon reduction to 1 V vs Li+/Li, a large capacity attributed to a conversion reaction and the reduction of Cu2+ to Cu0. Control of the formation of oxygen vacancies in Li-rich rocksalt oxides by selecting appropriate cations and synthesis conditions affords a new route for tuning the electrochemical properties of cathode materials for Li-ion batteries. Furthermore, the development of material models of the required level of detail to predict phase diagrams and electrochemical properties, including oxygen release in Li-rich rocksalt oxides, still relies on the accurate prediction of crystal structures. Experimental identification of new accessible structure types stabilized by oxygen vacancies represents a valuable step forward in the development of predictive models.Rapid and low-cost molecular analysis is especially required for early and specific diagnostics, quick decision-making, and sparing patients from unnecessary tests and hospitals from extra costs. One way to achieve this objective is through automated molecular diagnostic devices. Thus, sample-to-answer microfluidic devices are emerging with the promise of delivering a complete molecular diagnosis system that includes nucleic acid extraction, amplification, and detection steps in a single device. The biggest issue in such equipment is the extraction process, which is normally laborious and time-consuming but extremely important for sensitive and specific detection. Therefore, this Review focuses on automated or semiautomated extraction methodologies used in lab-on-a-chip devices. More than 15 different extraction methods developed over the past 10 years have been analyzed in terms of their advantages and disadvantages to improve extraction procedures in future studies. Herein, we are able to explain the high applicability of the extraction methodologies due to the large variety of samples in which different techniques were employed, showing that their applications are not limited to medical diagnosis. Moreover, we are able to conclude that further research in the field would be beneficial because the methodologies presented can be affordable, portable, time efficient, and easily manipulated, all of which are strong qualities for point-of-care technologies.Currently, the quest for highly transparent and flexible fibrous membranes with robust mechanical characteristics, high breathability, and good filtration performance is rapidly rising because of their potential use in the fields of electronics, energy, environment, medical, and health. However, it is still an extremely challenging task to realize transparent fibrous membranes due to serious surface light reflection and internal light scattering. Here, we report the design and development of a simple and effective topological structure to create porous, breathable, and high visible light transmitting fibrous membranes (HLTFMs). The resultant HLTFMs exhibit good optical performance (up to 90% transmittance) and high porosities (>80%). The formation of such useful structure with high light transmittance has been revealed by electric field simulation, and the mechanism of fibrous membrane structure to achieve high light transmittance has been proposed. Moreover, transparent masks have been prepared to evaluate the filtration performance and analyze their feasibility to meet requirement of facial recognition systems. The prepared masks display high transparency (>80%), low pressure drop (90%). Furthermore, the person wearing this mask can be successfully identified by facial recognition systems. GS-9674 chemical structure Therefore, this work provides an idea for the development of transparent, breathable, and high-performance fibrous membranes.