Comparative connectomics in the primate interpersonal mental faculties

Introduction High-intensity interval training (HIIT) and small-sided games (SSG) have been applied and tested for athletes in order to enhance the soccer performance. For this reason, this experimental study aimed to compare the effects of SSGs and HIIT on power, physiological responses and perceived enjoyment. Materials and Methods Sixteen youth soccer players (age, 17.5±0.6 years, mean±standard deviation; height, 178.2±6.4 cm; body mass, 70.4±5.4 kg; body fat, 10.6±0.8%) completed one session each of HIIT and SSG on separate days with 1 week between sessions. Each session lasted 25 mins (4x4 mins work with 3 mins of passive recovery in-between). SSGs consisted of 4 versus 4 player games on a 25×35 m pitch, and HIIT consisted of intermittent 15-s runs at 110% maximal aerobic speed separated by 15 s of passive recovery. Psychological responses following each protocol were assessed using the Physical Activity Enjoyment Scale (PACES). Myricetin molecular weight Heart rate (HR) was continuously recorded, rating of perceived exertion (RPE) and lactate concentration [La] were measured after each training session. Lower body muscular power was assessed using the 5-jump test relative to leg length (5JT-relative) before and after each training session, where greater average distance per stride over five sequential jumping strides indicated greater muscular power. Results HIIT and SSG showed no significant difference in HR, RPE and [La] responses (p=0.70, ES=0.11; p=0.61, ES=0.08 and p=0.38, ES=0.21, respectively). 5JT-relative decreased significantly for SSG and HIIT (p less then 0.05, ES=0.50 and p less then 0.05, ES=0.40, respectively). PACES score was greater in SSG compared to HIIT (ES=5.35, p less then 0.001). Conclusion HIIT and SSG sessions induced similar physiological responses; however, SSGs induced a higher enjoyment level than HIIT. Coaches could choose between these training modalities according to the objective of their training session, considering the enjoyment-related advantages of SSGs. © 2020 Selmi et al.Background Out-of-hospital cardiac arrest is the main issue for pre-hospital emergency care. There are several airway managements during the out-of-hospital cardiopulmonary resuscitation (CPR) such as endotracheal intubation (ETI) or alternative airway device bag-valve mask (BVM). Data comparing both methods showed inconclusive results on survival and limited results on CPR outcome. This study aimed to add additional results on comparing the ETI and BVM in cardiac arrest outside hospitals; focused on the CPR outcome. Methods This study was a retrospective, analytical study. The inclusion criteria were adult patients (age of 18 years or over) with out-of-hospital cardiac arrest, who received emergency life support, and received either BVM or ETI. Data were retrieved from the Information Technology of Emergency Medical Service. The outcome was a return of spontaneous circulation (ROSC). Results During the study period, there were 1070 patients with out-of-hospital cardiac arrest who met the study criteria. Of those, 800 patients (74.77%) received BVM, while the other 270 patients (25.23%) received ETI. There were five significant factors between both groups including mean distance to scene, proportions of response time less than 8 mins, defibrillation, intravenous fluid administration, and adrenaline administration. There was no significant difference on the outcome ROSC. The BVM group had slightly higher rate of ROSC than the ETI group (19.63% vs 15.56%; p value 0.148). Conclusion The BVM and ETI had comparable ROSC rate for out-of-hospital cardiac arrest victims. However, the study population of the BVM group had less severe conditions and received faster treatment than the ETI group. © 2020 Yuksen et al.Aim To assess the efficacy of the TriGUARD 3™, a novel cerebral embolic protection (CEP) device in reducing cerebral embolization by deflecting embolic debris away from the cerebral circulation using a quantitative in vitro model. Methods and Results This in vitro study assessed the ability of a cerebral embolic protection device to deflect embolic debris, by measuring the percent of particles and air bubbles, 200 µm and 300 µm in size, from entering the cerebral circulation compared to unprotected controls. A 3D printed silicone model of the ascending aorta, the aortic arch with its three major cerebral arteries and the descending aorta was connected to a custom-made simulator that mimics physiological pulsatile flow patterns of the left ventricle. Comparative analyses were used to assess the efficacy of the cerebral embolic protection device to deflect particles and air bubbles away from the major cerebral arteries. The percent of particles and air bubbles entering the major cerebral arteries was significantly lower with cerebral embolic protection compared to unprotected controls (p97% efficacy of the TriGUARD 3 CEP device, in reducing cerebral embolization of particulate and air bubbles of 200 µm to 300 µm in size. © 2020 Haiman et al.Purpose New medical devices that contain hyaluronic acid (HA) and chondroitin sulphate (CS), with or without antacid components, have been developed for the treatment of gastroesophageal reflux disease (GERD) with the aim of improving oesophageal mucosal defences by creating a film on the oesophageal mucosa and acting as a mechanical barrier against the noxious components of refluxate, both acidic and basic. Methods The film-forming and protective efficacy of medical device A based on HA and CS plus aluminium hydroxide, device B combining HA and CS with magnesium trisilicate and device C with only the combination of HA and CS was tested on a reconstructed human oesophageal epithelium (HO2E/S/5) as a biological model in 2 different pH environments, neutral and acidic, to mimic realistic conditions. Caffeine penetration kinetics and Lucifer yellow (LY) permeability modifications induced by these products were compared to those induced by a negative control series (saline solution, code NC) and positive control series (white Vaseline, code V) under neutral and acidic pH conditions. Results Under neutral and acidic pH conditions, compared to the negative control, all the products tested reduced (>80% and 85-90%, respectively) the caffeine passage, and no significant difference was observed among the products tested. Under neutral and acidic conditions, the LY permeabilities registered with device A and device C were not different from that registered with the negative control, while an LY flux% increase was calculated after 2 hrs of treatment (21.1%) with device B under acidic conditions. Conclusion These results confirm the ability of the products tested to interact with the oesophageal epithelium in order to adhere and create a stable protective film for at least 2 hours after their homogeneous distribution on the epithelium surface. Further clinical studies are needed to test these devices in the topical treatment of gastroesophageal reflux symptoms. © 2020 Pellegatta et al.