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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are usually characterized by a focus on practical aspects of the study design, including recruitment and consent, adherence, and the use of standard equipment.
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Pragmatic is a software company, offers a variety of casino games for online gambling platforms. Pragmatic's iGaming solutions are used by the leading operators and land-based casinos. The company provides front-end site design tools, analysis and marketing, promotions security payment systems, customer support, and bug reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics as well as gaming.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. However, too much heterogeneity can result in issues with the design of the trial.
Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers an array of traditional table games, including Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling and a wide range of virtual betting options. The company has also developed various interactive games to make online gambling fun. Some of these shows are hosted live, while others include famous people from the industry.
Mobile compatibility
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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. The company is licensed and is regulated by various regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. The games are protected by high-end encryption and the security team is always on hand to help players solve any issues they might have.
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Legality
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are typically ordered by policymakers and practitioners to help guide their decisions. They also provide a useful method to determine the cause-effect relationship between the intervention and its effects. However, they should not be used in lieu for explanatory studies.
The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a pragmatic trial which includes recruitment, design and delivery of the intervention, and follow-up.
There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary care settings.