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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. 프라그마틱 슬롯 사이트 are typically focused on the practical aspects of the study design, including the recruitment process and consent as well as adherence to the use of commonly available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from different geographic areas. This type of heterogeneity, that is crucial for pragmatic trials to be valid and reduce bias in results is also essential. Too much heterogeneity, however, can cause problems with the trial design.
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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. Usually, they are requested by practitioners and policymakers to inform their decisions. They are also a good method to determine the causality between the intervention and its effects. They should not, however be used to replace explanation studies.
The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a practical trial which includes the recruitment process, the design and implementation of the intervention, and monitoring.
There is a growing increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.