Computational Evaluation of Me2 TCCP as Lewis acid

As forward progress continues, coupling together a person's genomic and epigenomic patterns with the deciphering of information that resides within the noncoding or "dark matter" of the human genome will revolutionize all fields of health care and certainly medical nutrition therapy. The more information we obtain in this field, the more we recognize that nutritional needs are not determined by single SNPs alone. Rather, it is more accurate to say that families of genes function together in a network to regulate metabolic function and its relationship to specific nutrients. The days of one-size-fits-all thinking about dietary recommendations are being replaced by excitement about specific genomic and biometric-based personalized recommendations.Introduction Mercury is a toxic metal that exists in elemental, inorganic, and organic states. Humans are exposed to mercury through industrial sources, consumption of seafood, or healthcare. Over time, this compound can accumulate in the body and cause symptoms. The authors of this study report a case of mercury toxicity and the detoxification treatment regimen provided to the patient from a functional medicine standpoint. Case presentation The patient is a 62-year-old woman of Mexican descent with a past medical history of hypertension, insulin resistance, hyperlipidemia, and anxiety disorder who presented, after visits with multiple allopathic physicians, with worsening neuropathic pain, fatigue, short term memory loss, and RUQ abdominal pain. She was found to have 10 aged mercury amalgams and elevated blood levels of inorganic mercury. Amalgam removal was recommended, in addition to dietary changes, a natural supplement regimen, and manual/physical therapy. After following the treatment for one year, the patient experienced a 70% decrease in total blood mercury levels and a dramatic improvement of all her symptoms. Discussion This patient's chronic mercury toxicity from dental amalgams was effectively treated using a functional medicine approach to care. More studies are needed to compare pharmacologic versus supplemental chelation.Background A 23-year-old Caucasian female was diagnosed with Ulcerative Colitis (UC) and symptoms were successfully managed with the 5-Rs (e.g. remove, replace, re-inoculate, repair, and rebalance) gut restoration program. Case/intervention Diagnostic laboratory testing was initially utilized which identified microbial imbalances, vitamin D deficiency, and vitamin B12 deficiency. Nutrition therapy was then implemented over a course of 7 months, which included a whole foods elimination diet that was low in fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) and avoided leading allergens such as cow dairy, soy, gluten, and corn. Nutritional supplements were implemented in phases to aid in rebalancing gut bacteria, repair the mucosal lining, and correct nutritional deficiencies. After good dietary adherence and the 5-Rs program, the patient became 100% asymptomatic with no use of mesalamine suppositories for more than 6 weeks. Conclusion This case report demonstrates the effectiveness of the 5-Rs program approach for the successful management of UC. Long-term resolution was supported by the elimination of specific foods, nutrition supplementation, and stress management.Polycystic ovarian syndrome (PCOS) is a common cause of menstrual irregularity and hyperandrogenism in women of reproductive age. Conventional treatment is centered around the use of oral contraceptive pills (OCPs) to regulate menstrual cycles, protect against endometrial hyperplasia, and manage clinically evident androgen excess. Many women prefer to avoid OCPs due to concerns about risks and adverse effects, or simply because they desire a non-pharmacologic approach. We present the case of a young woman with a strong preference for a natural approach to her care who presented with PCOS manifesting in menstrual irregularity, acne, and hirsutism. In this case, acupuncture as well as the botanicals Vitex agnus-castus and diindolylmethane were used over a 10-month period. The patient regained menstrual cyclicity, and clinical and biochemical hyperandrogenism normalized. This report underscores the need for an integrative approach to the management of multifactorial disorders such as PCOS and highlights the basic science and clinical data supporting the use of acupuncture, Vitex agnus-castus, and diindolylmethane in patients with this condition.The leaves of Carica papaya have been used to treat thrombocytopenia in Dengue fever in areas where the virus is endemic. This case series describes the use of C. papaya leaf liquid extract (CPLE) as an adjunctive therapy for four patients receiving standard-of-care treatment for chronic immune thrombocytopenic purpura (ITP). https://www.selleckchem.com/products/bpv-hopic.html The cases presented here indicate that CPLE may prove beneficial in the management of chronic ITP for patients interested in alternative therapy before progressing to second-line treatments. A larger clinical trial is warranted to evaluate CPLE as an adjunctive therapy in chronic ITP.Through experiences gained over the past 3 decades, the development and application of the Functional Medicine model has demonstrated its ability to improve clinical decision making in the treatment of patients with complex chronic disease. The Functional Medicine model provides a system that effectively translates the emerging understanding of the gene-environment regulation of the structure and function of the individual into clinical practice.Foundational to the standard of care is diagnosis of overt disease as well as testing for early predictors of future disease. Obvious examples of the later include measurement of blood pressure and cholesterol. The time has come to add to this thinking early detection of the environmental causes of disease. Substantial research now shows that metal and chemical contamination of the environment has resulted in body loads of these toxicants at high enough levels to induce disease. The time has come to add screening for toxicant load to the standard of care.The patient was a 27-month-old girl a congenital defect involving the 47th chromosome who was referred to an acupuncture clinic for supportive treatment of Trisomy-18 (T-18). The condition results in severe medical complications, developmental delays and a shortened lifespan. This patient was unable to eat or swallow, unable to move, and had difficulty sleeping. Her parents and the flew to New Mexico from New York and the patient underwent four consecutive neuro-acupuncture treatments (also called scalp acupuncture). The treatment response was immediate resulting in dramatic sleep improvement, cessation of vomiting, beginning to eat, and improved ability to stand and subsequently move. Treatment effects have been sustained for more than one year.