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503, p=.005) and higher child BMI (β=0.531, p=.033). MVPA was associated with higher sleep efficiency (β=0.441, p=.016).
Household income emerged as a correlate of sleep variability and sedentary behavior in our study. In addition, we found that MVPA levels were associated with sleep efficiency.
Our results signal an impetus for further research (particularly with larger, multi-site study designs) examining study constructs among Latinx children.
Our results signal an impetus for further research (particularly with larger, multi-site study designs) examining study constructs among Latinx children.Fibroblast growth factor receptor 4 (FGFR4) is a member of the fibroblast growth factor receptor family, which is closely related to the occurrence and development of hepatocellular carcinoma (HCC). In this article, a series of indazole derivatives were designed and synthesized by using computer-aided drug design (CADD) and structure-based design strategies, and then they were evaluated for their inhibition of FGFR4 kinase and antitumor activity. F-30 was subtly selective for FGFR4 compared to FGFR1; it affected cell growth and migration by inhibiting FGFR4 pathways in HCC cell lines in a dose-dependent manner.To date, little is known about the effective doses of airborne particulate matter (PM) and PM-bound hazardous organic components to the human respiratory tract (HRT). In the light of this, here we provide particle mass dose rates (dose per hour of exposure) of PM and a suite of PM-bound hazardous organic compounds in the HRT for two population age groups (adults & children). More specifically, the mass dose rates of PM and PM-bound polycyclic aromatic hydrocarbons (PAHs), nitrated-PAH (NPAHs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) were estimated at two urban sites using a multiple path particle dosimetry model. We find that, in most cases, the total mass doses are following similar variations across sites and seasons as their ambient total concentrations, however their distribution in the HRT is a function of the particle size distributions and the physiological parameters of each age group. More specifically, the majority of the deposited mass of PM and all the chemical components investigated was accumulated in the upper airways instead of the lungs. We further show that children, due to their different physiology, are more susceptible and receive larger fraction of the total mass doses in the deepest parts of the lungs compared to the adults' group. Comparing the traditional method for estimating the inhalation risk, which is based on the ambient concentration of pollutants, and a modified version using the mass dose in the HRT, we find that the former may overestimate the reported risks. The results presented here provide a novel dataset composed by previously undetermined doses of hazardous airborne particulate organic components in the HRT and demonstrate that alternative health risk estimation approaches may capture some variabilities that are traditionally overlooked.
The proinflammatory state and metabolic changes associated with obesity contribute to cerebrovascular disease. Bariatric surgery can achieve a reliable reduction in body weight and improved metabolic profile in obese patients. However, its impact on cerebrovascular morbidity remains unexplored. This study investigates the effect of bariatric surgery on long-term risk of major cerebrovascular events.
A retrospective cohort study was designed. Data was extracted from the Clinical Practice Research Datalink. Ziritaxestat chemical structure 4212 bariatric surgery patients were compared to 4212 age, sex, and BMI-matched controls. The primary composite endpoint was occurrence of any major adverse cerebrovascular event. Secondary endpoints included composite endpoints of ischaemic events, haemorrhagic events, individual components of the primary endpoint alone and all-cause mortality. An adjusted Cox proportional hazards model was implemented to analyse time to event data.
Mean follow-up length was 11.4 years. The primary endpoint occurred in 73 patients. The bariatric surgery group had significantly lower adjusted major cerebrovascular event rates (HR 0.352, 95 %CI 0.195-0.637). Bariatric surgery was associated with lower rates of ischaemic events (HR 0.315, 95 %CI 0.156-0.635), particularly from transient ischaemic attacks (HR 0.364, 95 %CI 0.171-0.775). There was no difference in the rate of haemorrhagic events (HR 0.442, 95 %CI 0.147-1.330) or acute ischaemic stroke (HR 0.221, 95 %CI 0.046-1.054). In total 229 patients died during follow-up. Overall, all-cause mortality was significantly lower in the bariatric surgery group (HR 0.352, 95 %CI 0.195-0.637).
This study identifies an association between bariatric surgery and lower long-term risk of major adverse cerebrovascular events in patients with obesity.
This study identifies an association between bariatric surgery and lower long-term risk of major adverse cerebrovascular events in patients with obesity.
Traumatic Brain Injury (TBI) is the leading cause of death and disability in people aged under 40 in the UK. Many patients suffer residual deficits, which limits their functional recovery. The aim of this study was to determine independent predictors of functional outcome at 1-year post-TBI.
Utilising a prospective observational cohort design, 1131 consecutive adult admissions with non-recurrent TBI were recruited from the ED (Emergency Department). Using routine consultant-led follow up clinics, data was collected between August 2011 and July 2015. The Rivermead Head Injury Follow Up Questionnaire (RHFUQ) was used to measure psychosocial function at 1 year.
A multiple linear regression model showed that previous psychiatric history (p < 0.001), lower Glasgow Coma Scale (p < 0.001), a severe CT scan (p = 0.002), aetiology of assault compared to sport (p = 0.011) and falls (p = 0.005), initial unemployment (p < 0.001) and no job at 8-10 weeks (p < 0.001) after TBI had a significant association with a worse RHFUQ score at 1 year. Follow up rate was >90 %.
This study adds valuable information on the prognostic indicators of TBI recovery and possible targets for intervention. Future development of a validated prognostic model to predict long term functional outcomes after TBI will help improve long-term treatment of the condition.
This study adds valuable information on the prognostic indicators of TBI recovery and possible targets for intervention. Future development of a validated prognostic model to predict long term functional outcomes after TBI will help improve long-term treatment of the condition.