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mportant patient-reported outcome in DPN care.
To investigate the necessity of patient-specific dosimetry calculations using individualized models for hyperthyroid patients treated with radioactive iodine (RAI). This treatment modality was considered to be safe and effective; however, a recent publication indicated associations between greater organ-absorbed doses of RAI and risk of cancer death.
Ten patient-specific models which ranged in size were used (from 152.5 to 184cm in height and from 44 to 88kg in mass). The time-integrated activity coefficients (TIAC) were evaluated from the 2017 Leggett's model assuming 24h radioactive iodine uptakes (RAIU) of 30, 50, 70, and 90% and two intake routes for normal uptake (ingestion and injection). A set of
I S factors (mGy MBq
h
) from the patient-specific phantoms including 12 source regions were provided in this study. These S factors were used together with the new TIACs to present dose coefficients.
The MC-based patient-specific S factors were compared with the ICRP standard data and the variatis. It was concluded that CT imaging limited to the region from skull base to mid thorax (i.e., for organs with RAIT doses of >~50mGy with a dose of 150Gy prescribed to the thyroid) may be suggested and is clinically relevant because the normal organ dose increments are not greater than 10%.
~50 mGy with a dose of 150 Gy prescribed to the thyroid) may be suggested and is clinically relevant because the normal organ dose increments are not greater than 10%.
To determine the role of vascular endothelial growth factor (VEGF) in placental hypoperfusion in obesity.
The prospective study enrolled women with a first-trimester singleton pregnancy in Izmir, Turkey, between January and April 2011. Participants were divided into three groups obese (body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] >30) with cesarean delivery; normal weight (BMI <30) with vaginal delivery (NVD); and healthy controls (BMI <30) with cesarean delivery. Before delivery, serum C-reactive protein (CRP), and uterine and fetal Doppler measurements were taken. ReACp53 ic50 VEGF was evaluated immunohistochemically from the umbilical cord.
Overall, 109 women completed the study obesity group (n=13, 11.9%), NVD group (n=50, 45.9%), and control group (n=46, 42.2%). Serum CRP was higher in the obesity group than in the control or NVD groups (P=0.009). VEGF score was highest in the NVD group (9.39±3.11), and lowest in the obesity group (4.58±2.78) (P<0.001). VEGF score decreased by 0.81 for each increase in BMI of 1 (P=0.002).
Maternal obesity was related to decreased VEGF expression. Although not supported by Doppler findings, decreased VEGF expression owing to maternal obesity might trigger endothelial dysfunction and inflammation.
Maternal obesity was related to decreased VEGF expression. Although not supported by Doppler findings, decreased VEGF expression owing to maternal obesity might trigger endothelial dysfunction and inflammation.
This randomized open-label trial compared the efficacy and tolerability of vortioxetine (15mg/daily) with different antidepressants in the treatment of patients with burning mouth syndrome (BMS).
One and hundred fifty BMS patients were randomized into five groups and treated with either vortioxetine, paroxetine (20mg/daily), sertraline (50mg/daily), escitalopram (10mg/daily) or duloxetine (60mg/daily). The Visual Analogue Scale (VAS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A), and Clinical Global Impression Improvement (CGI-I) and Efficacy scales (CGI-E) were performed at baseline and after 2, 4, 6, and 12months of treatment. Any adverse events (AEs) were tabulated for each group. Descriptive statistics, including the Kruskal-Wallis non-parametric test and the Friedman non-parametric test for median comparisons between different times, were used.
All the antidepressants (AD) were associated with a significant decrease in the VAS, T-PRI, HAM-A, HAM-D, CGI-I, and CGI-E scores in the long-term (p<.001). However, the response rate of the vortioxetine group showed a significant reduction after six months. The medians, after 6months, were as follows VAS 0.0; T-PRI 2.0; HAM-A 7.0; HAM-D 7.0; CGI-I 1.0; and CGI-E 1.0 with a lower incidence of AEs (p<.019).
Vortioxetine was efficacious with a shorter latency of action and fewer AEs compared with other ADs.
Vortioxetine was efficacious with a shorter latency of action and fewer AEs compared with other ADs.Many studies using N2pc as a marker of attentional capture have demonstrated top-down contingent capture for salient color singletons Among all salient cues that are not predictive of the target location, only cues similar to searched-for target features, and thus, matching to the top-down attentional control settings capture attention. This is reflected in matching cue's elicitation of an N2pc and a cueing effect in behavior, and the absence of the corresponding effects for non-matching cues (with features dissimilar to that of the searched-for targets). Yet, with abrupt-onset cues, corresponding evidence is missing, inviting speculations about the potential of abrupt-onset cues to capture attention followed by quick suppression within the target displays. Here, we used two types of abrupt-onset cues to test if capture by such cues also adheres to the contingent-capture principle matching abrupt-onset cues with a color similar to the top-down control settings and non-matching abrupt-onset cues with a color different from all searched-for targets. With the help of these cues, top-down contingent capture was supported. Only matching abrupt-onset cues elicited an N2pc and a behavioral cueing effect. Depending on the exact side conditions, non-matching cues either elicited no N2pc or a PD (i.e., evidence of active suppression). Results are discussed against the background of competing theories on attention capture by abrupt-onset cues.
Viral respiratory tract infections are the leading cause of acute wheezing in children with a significant risk of hospital admission, risk of recurrence and subsequent asthma. Human respiratory syncytial virus (RSV) and human rhinovirus (RV) in childhood wheezing are widely studied; however, accessible PCR assays enabled diagnosis of other pathogens, including bocavirus (hBOV) and metapneumovirus (hMPV).
The aim of the study was to evaluate the prevalence of respiratory viruses in children hospitalized for acute wheezing along with demographic and clinical data.
We enrolled 101 children, n = 50 (49.5%) with wheezy bronchitis, n = 34 (33.7%) with acute bronchiolitis and n = 17 (16.8%) with exacerbation of asthma; (median age 1.41±2.84 years). Multiplex real-time PCR assay was used for virus detection.
One or more viruses were detected in 83.2% subjects RSV in 44.6%, followed by RV (23.8%), hBOV and hMPV (both 11.9%); other viruses were less frequent (<8%). Viral coinfection was found in 38 (37.6%) of children.