What Pragmatic Free Trial Will Be Your Next Big Obsession

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Pragmatic Play Free Trial
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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of study design which include recruitment and consent, adherence and the use of routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and participants from various geographical areas. This type of heterogeneity is necessary for practical trials to be valid and also helps reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
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Legality
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The aim of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used in lieu for explanatory trials.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study, including recruitment, design, implementation of the intervention, and follow-up.
There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.